Diagnostics Industry / Health

Ferritin and CRP elevated in pregnant women with PCOS

Ferritin and CRP elevated in pregnant women with PCOSWomen suffering with polycystic ovary syndrome (PCOS) have difficulties conceiving, and often have to take fertility medication and make lifestyle changes. However becoming pregnant is not the end of the struggle, it is more common for women with PCOS to experience pregnancy complications.

A new study published in the journal of clinical endocrinology and metabolism (1) looked at white blood cell count, CRP and ferritin, both low grade chronic inflammation markers to see whether levels changed during pregnancy. 150 pregnant women with PCOS were assessed, along with 150 age and BMI matched controls.

Results concluded that women with PCOS had a higher white blood cell count at the start of study compared to that of controls regardless of gestational age. By 12 weeks women with PCOS had significantly higher white blood cell and ferritin levels. CRP levels were also found to be raised once women reached twentieth week of gestation. Researchers used multivariable hazard analysis to determine that women with PCOS had elevated levels of inflammatory markers (including ferritin and CRP) which had an associated effect with increased risk for adverse obstetric and neonatal outcomes.   The hazard risk for CRP was 1.19 (95% CI, 1.06 – 1.34; p=0.19). The hazard risk for ferritin elevation was 1.12 (95% 1.03 – 1.26; p=0.11). The white blood cell count hazard risk was 1.52 (95% CI, 1.31 – 1.64; p=1.10).

The study authors noted that low grade chronic inflammation persists, is exacerbated by pregnancy and could play a crucial role in adverse pregnancy outcomes. The study authors further stated “to the best of our knowledge, [this] is the first clinical study aimed to evaluate several markers of low-grade chronic inflammation throughout pregnancy in a wide population of PCOS patients”.

Reference: The Journal of Clinical Endocrinology and Metabolism

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