Laboratory Quality Control

The importance of fully human laboratory quality controls

The importance of fully human laboratory quality controlsQuality control materials are used in clinical laboratories to help monitor analytical performance and detect errors but most importantly to ensure the accuracy and reliability of patient test results.  Ideally a quality control material should mimic a patient sample as much as possible in order to provide an effective method of assessing performance however this is not always the case.

Many control manufacturers in an attempt to keep costs low will add constituents of animal origin to their controls.  The inclusion of such non human components can create problems particularly with antibody based tests.  Different batches of reagent are likely to have been manufactured with different lots of antibody.  The non human components in the control will react very differently with each different lot of antibody resulting in significant shifts in control values when reagent batch is changed. Such shifts lead to a frequent need to reassign control materials causing frustration and an increase in costs.

The use of fully human quality controls is therefore essential for immunology and immunoassay based methods were the reagent contains human antibody.  As such all Randox Acusera controls designed for use with these methods are manufactured from 100% human materials.  This not only provides a matrix similar to the patient sample but reduces antibody cross reactivity and the risk of control values shifting when reagent batch is changed.  Can your current control manufacturer say the same?

In addition to our range of 100% human quality controls Randox can also provide bovine controls particularly suited to veterinary laboratories.

 

 

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