Cancer Diagnostics

IL-10, IFNy and other cytokines reduced by exercise of cancer patients

IL-10, IFNy and other cytokines reduced by exercise of cancer patientsPsychological stress is associated with an individual feeling under mental, physical or emotional pressure and can be brought on by a number of reasons. Cancer is known to increase these levels, and although there is no clear evidence to suggest stress affects patient outcome, studies have suggested that individuals may develop a sense of helplessness when stress becomes overwhelming, often having a detrimental effect on recovery.

Previous studies have shown that exercise in cancer patients, via a 6-week home based aerobic and resistance training program, (EXCAP- Exercise for Cancer Patients) has proved beneficial in decreasing fatigue; however the reduction in stress related cytokines such as IL-10 has not been considered.

New research discussed at the American Society of Clinical Oncology 2014 explained the importance that brief physical interventions could have on inflammatory cytokine levels in patients that may otherwise be unwilling to engage in more traditional forms of time-intensive psychotherapy.

Researchers assessed a test population of 58 prostate cancer patients with a mean age of 67 and randomized them into two clear groups:

  1. A group receiving 6 week EXCAP program
  2. Standard Care- control group

Psychological distress (derived from the profile of mood states) and cytokine levels of inflammatory biomarkers (IFNy, IL-6, IL-8, IL-10 sTNFR-I) were taken at baseline and post intervention (6 weeks follow up).Ā  Baseline levels of cytokines were accounted for and ANCOVA was used to determine the effects that EXCAP had on patient cytokine level. The Pearson model was then used to evaluate mechanistic associations between change in distress and inflammatory cytokine levels from pre and post analysis. Participants were also evaluated using a profile of mood state (POMS) total score, calculated by way of psychological questionnaire which then determines a participants stress levels.

When comparing the EXCAP participating group with the standard of care alone group the POMS score highlighted a reduction of distress within EXCAP participants (EXCAP M=5.17, SD=14.02; control M=2.43, SD= 8.06. P=0.02). Further to this EXCAP participants were associated with decreases in IL-10 (r=39, P=0.04) and IFNy (r=4, P= 0.03). These associations were not seen in the control group.

Reference: http://meetinglibrary.asco.org/content/133959-144

If you are interested in researching the effects that various cytokines have on the body, Randox Research offers numerous high quality multiplex cytokines arrays; allowing for a comprehensive panel of 35 cytokines, chemokines, cytokine receptors and growth factors, over five multi-analyte arrays to be simultaneously measured. Alternatively custom arrays can be created, allowing researchers to custom choose from over 300 biomarkers. For more information, download our Oncology Research Brochure or email: research@randox.com

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