Disease States / Lab News

New markers warn of progressive kidney problems after heart surgery

New markers warn of progressive kidney problems after heart surgeryMarkers found in blood and urine could possibly signify progressive kidney problems in patients who experience abrupt kidney injury following heart surgery. Doctors could potentially test for these markers to protect the health of patients after surgery.

Rapid decline in kidney function, or Acute Kidney Injury (AKI), are conditions which are increasing in prevalence. This rapid decline in functionality of the kidneys sometimes occurs after heart surgery due the deprivation of normal blood for an abnormally long period of time during the procedure.  Although most cases of AKI after surgery resolve relatively quickly, some cases worsen and the survival and health of the patient are in jeopardy.

Dr. Chirag Parikh from the Yale University School of Medicine and Dr. Jay Koyner from the University of Chicago, along with other colleagues, examined the urine and blood samples of 380 patients with AKI after heart surgery. They discovered that there are certain markers which are present on the day AKI is diagnosed. This could be an indication that there is structural injury to the kidneys which are likely to cause patients progressive problems. Two of these markers were albumin to creatinine ratio plus high high urinary interleukin-18. The risk of a patient experiencing persistent AKI were increased three-fold when these markers were present. High blood levels of the protein neutrophil gelatinase-associated lipocalin increased the patients risk by more than seven fold.

Dr. Parikh states that this multi-centre study is the largest study focusing on AKI biomarkers in adults. He believes it strengthens the concept that assessing structural injuries at the time of clinical diagnosis can yield important prognostic information about urine and blood markers of AKI. Dr. Parikh adds that he hopes future studies will use this study as a starting point for evaluating markers to  identify patients who are at high risk of AKI.

Reference: www.medicalxpress.com


Randox Laboratories provide test kits for the complete renal profile.  For more information, visit the Disease States section of the website.


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