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What is Metabolic Syndrome?

Metabolic Syndrome is a clustering of cardiovascular risk factors, (such as central obesity, raised blood pressure or triglycerides and raised fasting plasma glucose) and with approximately 20-25% of adults affected, it is highly prevalent. It is estimated that having Metabolic Syndrome leads to a person being three times more likely to have a stroke or heart attack, and five times more likely to develop diabetes. However, the pathophysiological processes leading to Metabolic Syndrome remain unclear, with no universally accepted definition.

Metabolic Syndrome has been defined by various different expert groups and associations, each using different sets of criteria, which reflect the contrasting views on the pathological mechanisms and clinical application.

Metabolic syndrome is a known risk factor for cardiovascular disease and diabetes, but researchers now report that it might also place individuals at higher risk for the development of liver cancer. Recent studies in India and the US have found that Metabolic Syndrome increases Liver Cancer risk. The authors of the US study found that 37.1% of patients with hepatocellular carcinoma and 29.7% with intrahepatic carcinoma had pre-existing metabolic syndrome. Conversely, only 17.1% of individuals without cancer had metabolic syndrome.

Along with already stipulated diagnostic criteria for Metabolic Syndrome, testing for other metabolic measurements such as Leptin, Adiponectin, Insulin C-reactive protein, Inflammatory cytokines (e.g TNF-α and IL-6) and PAI-I have been recommended by the International Diabetes Federation (IDF) consensus group as another method for diagnosis of Metabolic Syndrome.

The prevalence of Metabolic Syndrome in our population needs to be recognised as a growing problem which must be addressed, by means of initiating and supporting the necessary dietary and lifestyle interventions for preventing the development of metabolic syndrome, particularly in children and young adults.

http://www.randox.com/metabolic-syndrome-arrays.php

References

India
http://articles.timesofindia.indiatimes.com/2011-04-04/health/29380006_1_metabolic-syndrome-liver-cancer-hepatocellular-carcinoma

US
http://www.medpagetoday.com/MeetingCoverage/AACR/25762

One Comment

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