Disease States / Health

Depression, immune dys-regulation and coronary artery disease

Depression, immune dys-regulation and coronary artery diseaseThe relationship between depression and the prognosis of coronary artery disease (CAD) within individuals is well established, with over 60 prospective studies examining the link over the last 40 years (1). The link between immune dys-regulation and depression has now been further investigated by a new study (2) using Randox’s award winning multiplex Evidence Investigator analyser.

Lead study authors Dr.Rahimi and Dr.Ghayur carried out their research on a cohort of 462 participants with healthy controls having a mean age of 53.3 ± 11.5,54.8 ± 11.3, and 59.5 ± 11.3 in Group B (-), and Group A participants, respectively (P < 0.05):

  • Group A: 342 candidates undergoing angiography (either angiography +/-
  • Group B: 120 healthy control subjects

A sandwich chemiluminescent method was employed to simultaneously test serum levels for 10 cytokines: IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, TNF-α, MCP-1 and IFN-γ, and a statistical analysis was performed using SPSS version 11.5.

Results indicated a significant difference between the serum levels of IL-4, IL-6, IL-10, and MCP-1 when comparing subjects with CAD and healthy persons (P < 0.05). Further, when subjects were further split to those with and those without depression regardless of cardiovascular status, there was a significant difference in serum levels of IL-8 and IL-6 between the groups (P < 0.05).

It was also found that when the subgroup with features of CAD was selected and divided to those with and without depression, there was also a significant difference in serum levels of IL-8 and TNF-α (P < 0.05).

This leads to the assumption that the interaction between depression and CAD was most likely mediated by inflammatory mechanisms.


1. Frasure-Smith N, Lespérance F. Recent evidence linking coronary heart disease and depression. Can J Psychiatry. 2006; 51: 730–737.
2. Canadian Journal of Psychiatryhttp://ircmj.com/?page=article&article_id=17111

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